1. Target Identification

Aim
To identify genes and processes linked to the pathogenesis of diabesity and obesity and discover novel molecular drug targets.

Expected results
Identification of novel genes implicated in diabesity.
Validation of selected genes involved in diabesity.

2. Target Characterisation

Aim
To characterise potential drug targets using molecular physiological studies and integrative human biology.

Expected results
Clinical physiological studies of potential targets and their effects on metabolism, body weight and composition.

3. Target Validation

Aim
To validate targets using molecular genetic approaches in conjunction with phenotypic analyses.

Expected results
Identification of 4 -5 novel validated molecular drug targets.