Diabesity - novel molecular targets for obesity and type 2 diabetes
 
publications  
2004  
2005  
2006  
2007  
2008  

Publications 2008
The following 48 publications have arisen from DIABESITY in 2008:

Evaluating the role of LPIN1 variation on insulin resistance, body weight and human lipodystrophy in UK populations
KA Fawcett, N Grimsey, RJ Loos, E Wheeler, A Daly, M Soos, R Semple, H Syddall, C Cooper, S Siniossoglou, S O'Rahilly, NJ Wareham and I Barroso
Diabetes (2008)

Acetylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to Naloxone, but not that to GnRH in young men: evidence for at central inhibitory action of ghrelin in the gonadal axis
F Lanfranco, L Bonelli, M Baldi, E Me, F Broglio and E Ghigo
J Clin Endocrinol Metab (2008)

Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha
H Duez, JV Veen, C Duhem, B Pourcet, T Touvier, C Fontaine, B Derudas, E Baugé, R Havinga, VW Bloks, H Wolters, FH van der Sluijs, B Vennström, F Kuipers and B Staels
Gastroenterology (2008)

The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism
H Duez and B Staels
Diab Vasc Dis Res (2008) 5:82-88

QRFP43 stimulates the hypothalamic-pituitary-gonadal axis via GnRH in rats
SR Patel, KG Murphy, EL Thompson, M Patterson, AE Curtis, MA Ghatei and SR Bloom
Endocrinology (2008)

The nuclear receptor Rev-erb{alpha} is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages
C Fontaine, E Rigamonti, B Pourcet, H Duez, C Duhem, JC Fruchart, G Chinetti-Gbaguidi and B Staels
Mol Endocrinol (2008)

Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis
BM McGowan, SA Stanley, J Donovan, EL Thompson, M Patterson, NM Semjonous, JV Gardiner, K Murphy, MA Ghatei and SR Bloom
Am J Physiol Endocrinol Metab (2008)

Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional dependent fashion
MJ Vázquez, CR González, L Varela, R Lage, S Tovar, S Sangiao-Alvarellos, LM Williams, A Vidal-Puig, R Nogueiras, M López and C Diéguez
Endocrinology (2008)

The role of the transcription factor Sox4 in insulin secretion and impaired glucose tolerance
M Goldsworthy, A Hugill, H Freeman, E Horner, K Shimomura, D Bogani, G Pieles, V Mijat, R Arkell, S Bhattacharya, FM Ashcroft and RD Cox
Diabetes (2008)

Activation of Stat3 signaling in AgRP neurons promotes locomotor activity
A Mesaros, SB Koralov, E Rother, FT Wunderlich, MB Ernst, GS Barsh, K Rajewsky and JC Brüning
Cell Metab (2008) 7:236-248

Central insulin action regulates peripheral glucose and fat metabolism in mice
L Koch, FT Wunderlich, J Seibler, AC Könner, B Hampel, S Irlenbusch, G Brabant, CR Kahn, F Schwenk and JC Brüning
J Clin Invest (2008)

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
BF Belgardt, A Husch, E Rother, MB Ernst, FT Wunderlich, B Hampel, T Klöckener, D Alessi, P Kloppenburg and JC Brüning
Cell Metab (2008) 7:291-301

Dynorphin in pro-opiomelanocortin neurons of the hypothalamic arcuate nucleus
N Maolood and B Meister
Neuroscience (2008)

Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through eNOS expression in white adipocytes
L Tedesco, A Valerio, C Cervino, A Cardile, C Pagano, R Vettor, R Pasquali, MO Carruba, G Marsicano, B Lutz, U Pagotto and E Nisoli
Diabetes (2008)

11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function
KE Chapman and JR Seckl
Neurochem Res (2008) 33:624-636

Hypothalamic thyroid hormone in energy balance regulation
A Herwig, AW Ross, KN Nilaweera, PJ Morgan and P Barrett
Obes Facts 2008;1:2-2

Here, there and everywhere: the endocannabinoid system
R Vettor, U Pagotto, C Pagano and R Pasquali
J Neuroendocrinol (2008) 20 Suppl 1:iv-vi

Common variants near MC4R are associated with fat mass, weight and risk of obesity
RJ Loos, CM Lindgren, S Li, E Wheeler, JH Zhao, I Prokopenko, M Inouye, RM Freathy, AP Attwood, JS Beckmann, SI Berndt, KB Jacobs, SJ Chanock, RB Hayes, S Bergmann, AJ Bennett, SA Bingham, M Bochud, M Brown, S Cauchi, JM Connell, C Cooper, GD Smith, I Day, C Dina, S De, ET Dermitzakis, AS Doney, KS Elliott, P Elliott, DM Evans, I Sadaf Farooqi, P Froguel, J Ghori, CJ Groves, R Gwilliam, D Hadley, AS Hall, AT Hattersley, J Hebebrand, IM Heid, C Lamina, C Gieger, T Illig, T Meitinger, HE Wichmann, B Herrera, A Hinney, SE Hunt, MR Jarvelin, T Johnson, JD Jolley, F Karpe, A Keniry, KT Khaw, RN Luben, M Mangino, J Marchini, WL McArdle, R McGinnis, D Meyre, PB Munroe, AD Morris, AR Ness, MJ Neville, AC Nica, KK Ong, S O'Rahilly, KR Owen, CN Palmer, K Papadakis, S Potter, A Pouta, L Qi, P Kraft, SE Hankinson, DJ Hunter, FB Hu, JC Randall, NW Rayner, SM Ring, MS Sandhu, A Scherag, MA Sims, K Song, N Soranzo, EK Speliotes, HN Lyon, BF Voight, M Ridderstrale, L Groop, HE Syddall, SA Teichmann, NJ Timpson, JH Tobias, M Uda, P Scheet, S Sanna, GR Abecasis, G Albai, R Nagaraja, D Schlessinger, CI Ganz Vogel, C Wallace, DM Waterworth, MN Weedon, CJ Willer, AU Jackson, J Tuomilehto, FS Collins, M Boehnke, KL Mohlke, VL Wraight, X Yuan, E Zeggini, JN Hirschhorn, DP Strachan, WH Ouwehand, MJ Caulfield, NJ Samani, TM Frayling, P Vollenweider, G Waeber, V Mooser, P Deloukas, MI McCarthy, NJ Wareham and I Barroso
Nat Genet (2008)

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential For Normal Adipocyte Differentiation
VA Payne, N Grimsey, A Tuthill, S Virtue, SL Gray, ED Nora, RK Semple, S O'Rahilly and JJ Rochford
Diabetes (2008)

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin
M López, R Lage, AK Saha, D Pérez-Tilve, MJ Vázquez, L Varela, S Sangiao-Alvarellos, S Tovar, K Raghay, S Rodriguez-Cuenca, RM Deoliveira, T Castañeda, R Datta, JZ Dong, M Culler, MW Sleeman, CV Álvarez, R Gallego, CJ Lelliott, D Carling, MH Tschöp, C Diéguez and A Vidal-Puig
Cell Metab (2008) 7:389-399

Cannabinoid type 1 receptor: another arrow in the adipocytes' bow
L Bellocchio, C Cervino, V Vicennati, R Pasquali and U Pagotto
J Neuroendocrinol (2008) 20 Suppl 1:130-138

The thyrotropin-releasing hormone secretory system in the hypothalamus of the Siberian hamster in long and short photoperiods
FJP Ebling, D Wilson, J Wood, D Hughes, JG Mercer, PJ Morgan and P Barrett
J Neuroendocrinol (2008) 20:576-586

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans
AK Wermter, A Scherag, D Meyre, K Reichwald, E Durand, TT Nguyen, K Koberwitz, P Lichtner, T Meitinger, H Schäfer, A Hinney, P Froguel, J Hebebrand and G Brönner
Eur J Hum Genet (2008)

Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
JE Caminos, SB Bravo, CR González, MF Garcés, LA Cepeda, AC González, F Cordido, M López and C Diéguez
Reprod Biol Endocrinol (2008) 6:14

Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens
E Jerlhag, E Egecioglu, SL Dickson, L Svensson and JA Engel
Eur Neuropsychopharmacol (2008)

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system
B Kola, I Farkas, M Christ-Crain, G Wittmann, F Lolli, F Amin, J Harvey-White, Z Liposits, G Kunos, AB Grossman, C Fekete and M Korbonits
PLoS ONE (2008) 3:e1797

Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders
JM Mercader, E Saus, Z Agüera, M Bayes, C Boni, A Carreras, E Cellini, R de Cid, M Dierssen, G Escaramís, F Fernández-Aranda, L Forcano, X Gallego, JR Gonzàlez, P Gorwood, J Hebebrand, A Hinney, B Nacmias, A Puig, M Ribasés, V Ricca, L Romo, S Sorbi, A Versini, M Gratacòs and X Estivill
Hum Mol Genet (2008) 17:1234-1244

Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans
F Prodam, A Benso, E Gramaglia, B Lucatello, F Riganti, AJ van der Lely, R Deghenghi, G Muccioli, E Ghigo and F Broglio
Neuropeptides (2008) 42:89-93

Association of a homozygous nonsense Caveolin-1 mutation with Berardinelli-Seip Congenital Lipodystrophy
CA Kim, M Delépine, E Boutet, H El Mourabit, S Le Lay, M Meier, M Nemani, E Bridel, CC Leite, DR Bertola, RK Semple, S O'Rahilly, I Dugail, J Capeau, M Lathrop and J Magré
J Clin Endocrinol Metab (2008) 93:1129-1134

Elevated cocaine- and amphetamine-regulated transcript (CART)-immunoreactivity in the circulation of patients with neuroendocrine malignancy
P Bech, V Winstanley, KG Murphy, AH Sam, K Meeran, MA Ghatei and SR Bloom
J Clin Endocrinol Metab (2008) 93:1246-1253

Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability
R Nogueiras, M López, R Lage, D Perez-Tilve, P Pfluger, H Mendieta-Zerón, M Sakkou, P Wiedmer, S Benoit, R Datta, JZ Dong, M Culler, M Sleeman, A Vidal-Puig, T Horvath, M Treier, C Diéguez and MH Tschöp
Endocrinology (2008)

Preanalytical factors affecting RIA measurement of plasma Kisspeptin
R Ramachandran, M Patterson, KG Murphy, WS Dhillo, S Patel, A Kazarian, MA Ghatei and SR Bloom
Clin Chem (2008) 54:615-617

Effects of leptin on energy metabolism in beta-less mice
CS Asensio, D Arsenijevic, L Lehr, JP Giacobino, P Muzzin and F Rohner-Jeanrenaud
Int J Obes (Lond) (2008)

DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
Z Balazs, RA Schweizer, FJ Frey, F Rohner-Jeanrenaud and A Odermatt
J Am Soc Nephrol (2008) 19:92-101

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population

A Benrick, P Jirholt, I Wernstedt, M Gustafsson, J Scheller, AL Eriksson, J Borén, T Hedner, C Ohlsson, T Härd, S Rose-John and JO Jansson
Regul Pept (2008) 146:189-196

Rev-erb alpha gives a time cue to metabolism
H Duez and B Staels
FEBS Lett (2008) 582:19-25

Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents
E Egecioglu, B Stenström, SB Pinnock, LY Tung, C Dornonville de la Cour, A Lindqvist, R Håkanson, U Syversen, D Chen and SL Dickson
Regul Pept (2008) 146:176-182

Diurnal profiles of hypothalamic energy balance gene expression with photoperiod manipulation in the Siberian hamster, Phodopus sungorus
C Ellis, KM Moar, TJ Logie, AW Ross, PJ Morgan and JG Mercer
Am J Physiol Regul Integr Comp Physiol (2008) 294:R1148-1153

Estrogen enhances expression of the complement C5a receptor and the C5a-agonist evoked calcium influx in hormone secreting neurons of the hypothalamus
I Farkas, P Varju, E Szabo, E Hrabovszky, N Okada, H Okada and Z Liposits
Neurochem Int (2008) 52:846-856

Feeding Behavior in Rats Subjected to Gastrectomy or Gastric Bypass Surgery
MW Furnes, B Stenström, K Tømmerås, T Skoglund, SL Dickson, B Kulseng, CM Zhao and D Chen
Eur Surg Res (2008) 40:279-288

Immunohistochemical and in situ hybridization studies on glycine transporter 1 after transient ischemia in the rat forebrain
I Kalló, C Jekkel, E Hrabovszky, Z Jurányi, B Vida, A Járási, T Wilheim, LG Harsing, Jr. and Z Liposits
Neurochem Int (2008) 52:799-808

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism
E Rother, AC Könner and J Brüning
Am J Physiol Endocrinol Metab (2008)

LDL-cholesterol concentrations: a genome-wide association study
MS Sandhu, DM Waterworth, SL Debenham, E Wheeler, K Papadakis, JH Zhao, K Song, X Yuan, T Johnson, S Ashford, M Inouye, R Luben, M Sims, D Hadley, W McArdle, P Barter, YA Kesaniemi, RW Mahley, R McPherson, SM Grundy, SA Bingham, KT Khaw, RJ Loos, G Waeber, I Barroso, DP Strachan, P Deloukas, P Vollenweider, NJ Wareham and V Mooser
Lancet (2008) 371:483-491

Cholinergic afferents to gonadotropin-releasing hormone neurons of the rat
GF Turi, Z Liposits and E Hrabovszky
Neurochem Int (2008) 52:723-728

IL6 and IL1B Polymorphisms are Associated With Fat Mass in Older Men: The MrOS Study Sweden
L Strandberg, D Mellström, Ö Ljunggren, E Grundberg, MK Karlsson, AH Holmberg, ES Orwoll, AL Eriksson, J Svedberg, M Bengtsson, C Ohlsson and JO Jansson
Obesity (Silver Spring) (2008) 16:710-713

PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism
M Vinciguerra, C Veyrat-Durebex, MA Moukil, L Rubbia-Brandt, F Rohner-Jeanrenaud and M Foti
Gastroenterology (2008) 134:268-280

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
C Pecqueur, T Bui, C Gelly, J Hauchard, C Barbot, F Bouillaud, D Ricquier, B Miroux and CB Thompson
FASEB J (2008) 22:9-18

Modified glutamine catabolism in macrophages of Ucp2 knock-out mice
T Nübel, Y Emre, D Rabier, B Chadefaux, D Ricquier and F Bouillaud
Biochim Biophys Acta (2008) 1777:48-54

Diabesity: Novel molecular targets for obesity and type 2 diabetes
   
  home | research | publications | members | events | about diabesity | press | links | contact us